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Flow chemistry
Application

We offer a variety of products useful for flow chemistry, including automated synthesizers and reactors.

© DFC-Device for Flow Chemistry
© DFC-Device for Flow Chemistry

What is Flow Chemistry?

Flow chemistry involves reactions that are run continuously in a fluid, achieving high yields and selectivity and enabling efficient synthesis. Flow chemistry is an integral part of pharmaceutical synthesis or synthetic organic chemistry.

Comparison with conventional synthesis

Conventional organic synthesis
Next-generation organic synthesis

In contrast to conventional organic synthesis in which multiple solutions are placed in a vessel to undergo processes such as temperature control and stirring, this approach newly uses microfluidic channels made of microfabricated glass or stainless steel through which solutions flow for synthesis.

Three Advantages of Flow Chemistry

  1. Precise temperature control

    Increased specific surface area accelerates heat exchange.

  2. High-speed mixing

    Short diffusion distance enables high-speed mixing and uniform reaction.

  3. Easy control of reaction time

    Residence time for which a solution remains in the reactor is controllable by regulating the flow rate.

Product Information

Automated synthesizer

OptimFlow

This automated synthesizer for drug discovery research can automatically synthesize multiple small-volume samples for up to 100 experiments. Ideal for pharmaceutical seed discovery.

Application notes
  1. No.1　Photo Minisci reaction:2-liquid mixture reaction
  2. No.2　Photo Minisci reaction: 3-liquid mixture reaction
  3. No.3　Superheating Mizorogi-Heck reaction:2-liquid mixture reaction
  4. No.4　Grignard reaction:2 + 1 mixture reaction
  5. No.5　Water-prohibition reaction using nBuLi:3-liquid mixture reaction
Automated synthesizer for process research

AltaFlow

The AltaFlow can automatically switch reagents, change flow rate, and regulate reactor temperature to automate the condition setting procedure.
FC-F-PP Series

Plunger pumps

With the ability to feed a liquid with a low pulsating flow, the pump is ideal to feed liquids for flow synthesis. Compatible with the OptimFlow and the AltaFlow.
FC-BPV1 Series

Compact back pressure valves

This palm-sized, compact back pressure valve enables intuitive regulation of back pressure by simply turning the knob.With its small internal volume, the valve can regulate the back pressure quickly even at low velocities.
FC-ABPR Series

Automated back pressure valve units

The unit includes a pressure sensor to automatically regulate the back pressure to a preset value.
FC-PHR Series

Photoreactors

The photoreactor can regulate the temperature with cyclic water. This adjustable device enables scaling up with minimal changes in the reaction conditions.
FC-TH Series

Tube heaters

The heater features the replaceable tube and can regulate the temperature of the reaction solution. This compact heater is suitable for multi-stage reactions.
FC-PSU-1000

In-line pressure gauge unit

This pressure gauge unit can measure in-line pressures and display pressures of two channels. The pressure sensor unit and the display unit can also be purchased individually.
FC-ECR-1.0

Electrolytic reactor

The electrodes of the reactor are easily replaceable. The reactor is also easy to disassemble and reassemble for internal cleaning.
FC-CC-KF Series

Columns filled with catalysts

SUS columns ideal for flow synthesis are filled with catalysts* with low pressure drops. *(Kawaken Fine Chemical Co., Ltd.)

Video

The introductory video will familiarize you with the product system.

Optim Flow, an automated small-volume, multi-sample flow synthesizer for drug discovery research

Contact

If you have any questions about our products or would like to request a quote,
please contact us by the inquiry form.

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